OVULATION DETECTION IS A MUST – BECAUSE BRAIN-OVARY PACEMAKERS SYNCHRONIZATION IS THE PREREQUISITE OF OVULATION

Whether a woman wants to use Fertility Awareness to help her get pregnant or to avoid getting pregnant, here is the thing about the underlying mechanism called folliculogenesis:

Folliculogenesis is not merely a process involving hormonal signals – it’s a process of integration of all neuroendocrinological inputs, which the cervix monitors. And our Ovulona biosensor monitors the cervix.

The ovulographic monitoring of folliculogenesis in vivo is understood to capture the fine-tuning effects on folliculogenesis of the direct neural control via ovarian and uterine innervation and the acute effects of local (autocrine and paracrine) modulatory actions. Those effects cannot be detected by the systemic peripheral variables such as the BBT or the urinary levels of hormones monitored by the commercially available home-use technologies.

The ovulographic monitoring of folliculogenesis in vivo can determine the 3 days of the so-called fertile window even when the timing is affected – as often happens – by stress, which is discussed in  https://biozhena.wordpress.com/stress-and-fertility-fertile-window-ovulation/ .

Non-baseline cycle w delayed ovulation- algor applied AND next cycle, no ovu delay - e1

The image illustrates (click it to enlarge) the Ovulona menstrual cyclic profile algorithm’s ability to address an effect of stress on the fertile window and ovulation timing. Refer for more to the page linked above the image.

In summary: The slow rate of descent of the Ovulona signal from the short-term predictive peak to the ovulation marker trough (nadir or minimum) in cycle 4 indicates an extended period of time required for the circhoral and the circamensual pacemakers (of the brain and of the ovary, respectively) to synchronize as the absolute precondition of ovulation.

THIS REQUIREMENT OF BRAIN-OVARY SYNCHRONIZATION,

WHICH IS THE MANDATORY PRECONDITION FOR OVULATION TO OCCUR,

IS A FUNDAMENTAL PRINCIPLE.

It is further speculated that an alternative synchronization activity is reflected on the descending branch of the long-term predictive peak in the cyclic record of cycle 5, which was recorded by the same woman in her menstrual cycle following after the cycle with the delayed ovulation (cycle 4).

The information-rich and interpretable features of the menstrual cyclic profile make this possible (see better how in the interpretable features link). The star-marks in the image below highlight how the Ovulona captured the two alternative mechanisms of brain-ovary synchronization, the precondition of ovulation.

A reminder: Ovulation is detected as the lowest minimum (nadir) in the graph of the daily menstrual cycle readings, after the long-term and short-term predictive peaks. That’s due to a switch at ovulation from estrogen dominance to progesterone dominance.

This switch is quite dramatic, and even the peripheral hormone measurements reflect that. For example, salivary steroid concentrations on ovulation day are: estradiol 8 pmol/l and progesterone 110 pmol/l.

Non-baseline cycle w delayed ovulation- algor applied AND next cycle, no ovu delay - e2 (arrests), stars

 

Let’s reiterate that folliculogenesis is a process of integration of all neuroendocrinological inputs, which the cervix monitors, and the Ovulona sensor monitors the cervix.

 

Hypothalamus-P-G Feedback and innervation panorama with text (stress)

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Folliculogenesis In Vivo™ cervix monitoring technology provides longitudinal signature records of the menstrual cycle vital sign.

 

 


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