Posts Tagged ‘birth control’

Why too many young and not so young ladies could NOT receive flowers on Mothers’ Day: Why so many trying-to-conceive, why so much infertility

May 14, 2012

Say thank you to the social and medical advances of the twentieth century – primarily those of chemical birth control, the Pill.

Yes, chalk it to the great advancements! Sarcasm aside, indisputable developments in society and in medicine have resulted in the present state of affairs.

Incidentally, “Mothers’ Day (with the plural) is how it was spelled in the U.S. congressional resolution first recognizing it, 9 May 1908”. That was before all this started, before Margaret Sanger wrote “What Every Girl Should Know”, before she started a radical feminist monthly “The Woman Rebel”, and released 100,000 copies of “Family Limitation”. It was before “her confrontational style attracted even greater publicity for herself and the cause of birth control.”

Margaret Sanger

Margaret Sanger
http://www.nyu.edu/projects/sanger/secure/aboutms/index.html
She wanted to liberate women.

Some years later, in the late 1920s – early 1930s, the Japanese Dr. Kyusaku Ogino (Professor at Niigata, Japan) and Dr. Hermann Knaus in Austria (University Women’s Clinic in Graz, Austria) independently discovered that women can conceive only during a brief period “in the middle of the menstrual cycle” [The Eugenics Review: Volume 28, 1936]. But – while this was the fundamental discovery of the menstrual cycle – pretty much right away there was the similarly fundamental criticism that “the so-called safe period of Knaus and Ogino offers very small protection indeed”.

That was because, for reproductive management, “the theories of Knaus and Ogino have not yet been proved sufficiently reliable for us to recommend the so-called safe period as a method of contraception…” although, “if the theory is correct, there will be more likelihood of impregnation at this time.”

Ngram 11 Number of books about Knaus and Ogino versus years 1900 to 2008

Ngram 11 showing the number of English-language books with the phrase Knaus and Ogino between the years 1900 and 2008 (the latest year of available data; at smoothing 3 )
http://books.google.com/ngrams/graph?content=Knaus+and+Ogino&year_start=1900&year_end=2008&corpus=0&smoothing=3
The second, higher, peak is indicative of the relationship between the practical failure of Ogino and Knaus and the inception of the oral contraceptive pill, which provided the answer to the failure.              (For the record, the following 2008 books give good reviews of the Ogino-Knaus story in the history of reproductive management: http://books.google.com/books?id=sqwMrennRsQC&pg=PA205&dq=%22Knaus+and+Ogino%22&hl=en&sa=X&ei=39uzT5uYKeWq2QXGmrDpCA&ved=0CEgQ6AEwAg#v=onepage&q=%22Knaus%20and%20Ogino%22&f=false     AND     http://books.google.com/books?id=RmpMZ7K2L3YC&pg=PA142&dq=%22Knaus+and+Ogino%22&hl=en&sa=X&ei=JsiyT6zXCKbM2AXf3-DpCA&ved=0CEIQ6AEwAQ#v=onepage&q=%22Knaus%20and%20Ogino%22&f=false   —    found via   https://www.google.com/search?q=%22Knaus%20and%20Ogino%22&tbs=bks:1,cdr:1,cd_min:1997,cd_max:2008&lr=lang_en)

Then again, “there is a good deal of evidence to prove the existence of these fertile and sterile periods”, and an author in 1945 “gives his opinion that the period during which the mammalian egg is susceptible to fertilization may be measured”. It was eventually recognized that the extent of the fertile period should be only 3 days, and that the basic practical problem was the variability of the menstrual cycle, essentially of the follicular (“proliferative”) phase, the one before ovulation.

However, we were not around with the Ovulona™ to measure the fertile period, and Mrs. Sanger’s zeal took her in the direction of a “magic pill”. In view of the failure of the first effort at natural approach to reproductive management, the so-called rhythm method, her direction is not too surprising because it was the time of great pharmaceutical advances. The chemists had the bandwagon of steroid chemistry to ride and Dr. Gregory Pincus had pioneered in vitro fertilization in the rabbit, for which he was not admired but more or less ostracized.

“In 1953, Margaret Sanger and Katharine McCormick (a heir to major millions of dollars) confronted Pincus with the idea of creating an oral contraceptive”, and the rest is history – of the Pill. History of the oral contraceptive pill and the ensuing sexual revolution. Do check out under P (Pill, the) in the Alphabet of bioZhena, and don’t miss also under M the article about “Mysterious conceptions (OR THE NONEXISTENCE THEREOF)”.

And then – now – there are the consequences of the Pill, one of which translates as the absence of the mother status in the lives of many women desiring motherhood. Those who are unsuccessfully trying to conceive, and so the bouquets of Mothers’ Day are only for their Moms.

Look how there was no infertility and no IVF before contraception. See the blue curve of infertility in the bottom graph, and the green curve of IVF in the top graph of books plotted against the years of the 20th century. See how they go up only years after the rise of contraception (bottom) and after birth control and family planning (top).

Ngrams 12 and 3 together

Ngrams 12 and 3 together showing the number of English-language books with the phrases birth control, family planning and IVF (Ngram 12, top) and contraception and infertility (Ngram 3, bottom)
between the years 1900 and 2008 (the latest year of available data; at smoothing 3 )
Ngram 3 data from http://books.google.com/ngrams/graph?content=birth+control&year_start=1900&year_end=2008&corpus=0&smoothing=3 , and Ngram 12 data (note: twice as high amplitude, top graph) from http://books.google.com/ngrams/graph?content=birth+control%2Cfamily+planning%2CIVF&year_start=1900&year_end=2008&corpus=0&smoothing=3

I have discussed the consequences of the steroid chemical contraception technology in several posts in this bioZhena’s Weblog. The consequences are numerous because of the far-reaching significance of tinkering with reproductive physiology – consequences for women’s health, and for public health.

Check out the Table of Contents = links to bioZhena posts. See, for example:

About atrophy, reproductive aging, and how it’s really not nice to fool Mother Nature – or with (For people outside of NFP [Natural Family Planning] because NFP people know this already)

The perils of IVF, of ARTs, of giving birth at old maternal age. (About epigenetic evidence that should make you think twice+ before you contemplate In Vitro Fertilization and think that having a baby can wait. The bottom line? Be a young mother!)

Difficult to conceive – Google evidence that pregnancy complications and trying-to-conceive concerns shot up after the Pill launch in 1960s (Regardless of what contraceptive proponents tell you)

Along the way to the unfortunate consequences of the anti-ovulation, anti-conception Pill and its modifications (modified methods of delivery of the chemicals into the female organism) there has been the effort to replace the calendar or rhythm method with different means of prediction of the ovulation day. I am referring to Natural Family Planning (NFP) and/or to the somewhat more recently labeled Fertility Awareness Based Methods (FABMs), one of which is the Fertility Awareness Method (FAM) itself. Fertility awareness (as opposed to the calendar) is key.

Some proponents will include NFP within FABMs and, of course, define NFP as requiring sexual abstinence during the fertile phase (fertile window) of the menstrual cycle; as opposed to FAM, which is defined as the use of a barrier method of contraception (such as a condom) during the fertile phase (fertile window).

Either way, the extent of the fertile window has always been THE major issue or rather the issue has always been the need for accurate and reliable determination of the fertile days. Only our Ovulona can determine the mere 3 fertile days due to the lifetimes of the sperm and of the ovum, egg. No other technique can.

Natural Family Planning or more broadly the FABMs cannot win if they continue to rely on what we have called (politely) the peri-ovulation methods of guesstimating the fertile window. Whether used to assist conception or to avoid it, ovulation calculators, calendars and circulating hormone detectors will not do. Scientific Fertility Assessment™ based on Follliculogenesis In Vivo™ is the only way to stop the unhealthy chemicalization of reproductive health management.

Gil Bruvel, Relative Time (1993)

Gil Bruvel, Relative Time (1993)
http://www.liveinternet.ru/tags/surrealism/page7.html
An interesting title. Each woman has her own biological clock, which responds to her circumstances in every individual menstrual cycle. That is why there is no such thing as cycle regularity (despite the long-held simplistic belief to the contrary).
In 1970, Dr. Hugh J. Davies of Johns Hopkins University told the US Senate in the Nelson Hearings about the contraceptive Pill: “Never before in history have so many people taken such powerful medication with so little information as to its actual and potential risks. …With the introduction of such active ingredients, we are actually setting up a massive endocrinological experiment with millions of healthy women.”

Natural family planning was a significant refinement of the fundamental discovery of Ogino and Knaus, developed as an alternative to the artificial chemical contraception. For decades the NFP proponents, along with OBGYNs and birth control advocates, erred on the (off-putting) long side of guesstimating the fertile window from various signs of the approach of ovulation.

Before it was officially – and incorrectly – decided in 1995 that there were 6 fertile days (all before and including the ovulation day), the period of abstinence required by NFP was advocated as at least 10 or 13 days long. A bit too much, to say the least – and, naturally, without monitoring the variable pre-ovulation phase to quantitatively anticipate ovulation, the failure rate was too high for birth control.

Logically, the same goes for “the other side of the coin”, for conception and pregnancy achievement. Again, please see certain other posts in this blog for more – you’ll recognize the pertinent articles in the table of contents.

One example of such a post is “Major studies decades ago revealed variability of menstrual cycles” (But people are still naïve about the basic cause of the difficulty to achieve pregnancy).

The NFP and FABM approaches to birth control have managed to avoid being nicknamed “the Vatican roulette” – unlike the rhythm/calendar method of Ogino and Knaus, the pioneers of the fertile and sterile periods who discovered the menstrual cycle. However, without our Ovulona™ the NFP and other fertility awareness methods are not reliable and, despite the NFP popularity in numerous countries, they are not any more suitable for birth avoidance than “the Vatican roulette”. Without the definitive determination of the fertile days, they are not approved for avoiding conception, and tend to be utilized for aiding conception.

That’s because, in the proceptive use (promoting conception), the methods’ lack of reliability only translates into an extended time of trying to conceive rather than into an unwanted pregnancy. Only! Fertility awareness tends to be utilized for aiding conception by focused intercourse because of the high prevalence of the difficulty to conceive. And focus is about all that those methods do, which helps (even if at least half is misfocused, if you take my meaning, if you see what I mean). The probability of conception increases with focus on the fertile window of opportunity. That’s fundamental, too.

People have a hard time accepting that getting pregnant is not as easy as expected, when they finally decide to want a baby – usually way too late, and after her use of the Pill. The drug makes healthy young women in their best years to postpone family- baby-making, it damages their cervical S-crypts thus causing difficulty to conceive and, by encouraging promiscuous sex life, it has caused an enormous increase in the prevalence of sexually transmitted diseases that also lead to infertility. Not just a double whammy, a triple whammy on womankind.  Sad, sad, sad.

The underlying principle of the predicament of unfulfilled yearning for a baby is highlighted in the second half of the caption or legend accompanying the Toyen painting just below – an image of futile waiting. (Highlight extracted as the briefest of summaries from https://biozhena.wordpress.com/2010/05/25/difficult-conception-tied-to-pregnancy-complications-addressed/.)

Toyen, Spící (1937)

Toyen, Spící (1937)
http://kultura.idnes.cz/podivejte-se-jak-vypada-marne-cekani-od-toyen-ktere-se-drazi-za-20-milionu-1ak-/vytvarneum.aspx?c=A090312_102133_vytvarneum_jaz
The painting’s title means Sleeping. The title of the referenced source, a media article, says : Look what futile waiting by Toyen looks like…
See Description of the image file for more about Toyen: https://biozhena.wordpress.com/2012/05/14/why-too-many-young-and-not-so-young-ladies-could-not-receive-flowers-on-mothers-day-why-so-many-trying-to-conceive-why-so-much-infertility/toyen-spici-1937/
It is not likely that Toyen would have had this in mind, but I present her art to highlight the predicament of unfulfilled yearning for a baby.
To highlight this:The chances of becoming pregnant are critically dependent on whether the insemination (natural or artificial) occurs at the right time, within the fertile window. This is because the probability of pregnancy is a combination of four individual probabilities: 1. Probability of being in good health, 2. of successful insemination, 3. of not miscarrying the conceptus (early embryo), and 4. the probability of correct timing of the baby-making intercourse. For example, a 60% success rate of correct timing brings the overall probability of pregnancy down to a mere 36%, and this goes down to a mere 30% if correct timing probability is only 50%, in healthy fertile couples – assuming the probability #3 (not miscarrying the conceptus) at an optimistic 75%. Even if the probability of determining the insemination time correctly were 90%, the resulting probability of successful pregnancy from any one particular insemination event would be only 55%. Get this! Only 55% under perfect ideal conditions, which include a young healthy unstressed woman. 

Advanced age of the would-be Mum works against her on account of the Mother Nature’s Probabilistic Rules and Regulations of Baby-Making: Good health and successful insemination probabilities are degraded whereupon the strict Natural Eugenicist suppresses the conceptus. So that, most often, the hCG pregnancy marker does not even have a chance to be detected – after the nerve-wracking 2-week wait – by the not-so-young Mum-candidate’s HPT [Home Pregnancy Test]. Needless to say that, all the more the not-so-young motherhood aspirant needs to enhance the fourth element of the equation, the probability of correct timing of the hoping-for-baby sex.

And all this because the young lady used the Pill during the years best suited for baby-making, and as a consequence she is not-so-young any more. It’s not nice to fool Mother Nature! Or with…

Therefore, I conclude this blog post by disputing the positive and admiring message in the concluding paragraph in the above-cited article “The Birth of The Pill”. They write: “Margaret Sanger dreamt of the idea of a birth control pill since she was a young woman. If she wasn’t confined to the boundaries of her time, she and McCormick could’ve researched and funded The Pill without the help of any male doctors or scientists. Unfortunately, the society that they lived in would not allow them to do so; they did go as far as they could. Many of their achievements go unnoticed, but both women were really the leading forces behind the development of The Pill.” QUOTE UNQUOTE.

Yes, indeed, Margaret Sanger and Katharine McCormick were the leading forces in the inception of chemical contraception. Driven by a social, political agenda (with “can do” in lieu of needed biomedical insight), they imposed on women, and hence on humankind, a simple-minded solution “as simple as taking an aspirin”. But, then… the consequences … among them an enormous increase in the incidence of sexually transmitted infections, contributing to the epidemic of infertility.

And that’s only for openers, as the saying goes. Referring to https://biozhena.wordpress.com/2012/04/18/the-perils-of-ivf-of-arts-of-giving-birth-at-old-age-part-2/: Detrimental effects on the offspring and – via epigenetics – on the health of future generations. Iatrogenic medicine kicking Hippocrates where it hurts the most. Also, therefore, quite the opposite effects with respect to the eugenic vision of Mrs. Sanger. Ironic, isn’t it.

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More About Clomid, Serophene, Clomiphene citrate or Clomifene

June 25, 2010

Why popping pills is not the best. This chemicalization of life is a form of enslavement.

Expanding on the previous post, I reiterate what I left off with. It is advisable – and safer – to go about TTC, Trying To Conceive, without the use of chemicals, especially man-made chemicals – and note that herbal preparations are chemicals too. Monitoring (measuring) the effects of anything [any drug] you ingest is basically a must, if you do not play “Russian roulette” with yourself, your offspring, your family.

There is no such thing as a “magic bullet”, and every drug has side effects. It is advisable – and safer – to go about TTC by mastering the natural “right time” approach. The medical establishment has approved of it for birth control, even if not all medical schools teach it. (Go figure.)

Of course, this is the era of popping pills, but it might also be the tail of the era, if web 2 social networking and all that is really here to stay… (Please don’t say, “you wish” about the tail!) The pressure of big pharma advertizing is what makes for said era. In the Middle Ages, they who were accessible to the then lobbying pressures, had things like the Crusades, witch-hunts, and stuff like that. Now, there are different pressures and more customers accessible to them…

An Angel Leading the Crusaders to Jerusalem - Gustave Doré (1832 - 1883)

An Angel Leading the Crusaders to Jerusalem - Gustave Doré (1832 - 1883)

But, back to Clomid, clomiphene, now spelled clomifene. This http://www.early-pregnancy-tests.com/clomid.html is one of the many websites about the drug. It warns that “…in the case of clomid and FertilityBlend/FertilAid, the product makers do state that clomid should not be taken with herbal products…”.

Looking at the chemistry of the non-steroidal ovulatory stimulant Clomid (or clomifene), http://to.ly/5dn2, and keeping in mind the inevitable occurrence of metabolic biochemistry (drug transformation in the body of the patient), one finds this title:

Stilbenoids: Resveratrol, Tamoxifen, Diethylstilbestrol, Combretastatin, Pterostilbene, Clomifene, Stilbenoid, Combretastatin A-4, Kobophenol A – at http://to.ly/5dm1.

Simply put, these medicinal compounds are differently substituted stilbenes (http://to.ly/5dQa = chemically modified stilbenes [stilbene being an ethene double bond with phenyl groups on both carbon atoms of the double bond]). Here is the pharma business in a nutshell: The different substituents (or modifiers attached to the stilbene molecule) impart different electronic, electrochemical, biochemical and physiological activities. That’s what the pharmaceutical industry explores in or with their products.

Albrecht Durer - Christ among the Doctors. 1506.

Albrecht Durer - Christ among the Doctors. AD 1506.

Then, we have a search for triphenyl ethylene stilbene http://to.ly/5dkt . Some of the search results are as follows – with particular reference to the fourth one below the recumbent woman (where anthropogenic means “caused or produced by humans”, and endocrine, of course, pertains to an endocrine gland or its secretion into blood or lymph):

OESTROGENS AND PRO-OESTROGENS RELATED TO STILBENE AND TRIPHENYLETHYLENE http://joe.endocrinology-journals.org/cgi/content/abstract/3/1/168 . “It has recently been shown [Emmens, 1941, 1942] that oestrogensmay be divided into two classes—those which act directlyor with changes that can be effected locally…” (Yes, shown in the forties.)

Estrogens and antiestrogens I: physiology and mechanisms of action …, Volume 1 (1999) http://to.ly/5dkx . “The most prominent drug amongst these compounds is tamoxifen…”

1993: RU 486—A Decade on Today and Tomorrow http://www.nap.edu/openbook.php?record_id=2203&page=71 . “The development of RU 4861 (Figure B1.1), the first efficient antiprogestin, may be seen as a result…this meeting, which merged science (hormone research) and the cause des femmes… it became clear that the available contraceptive methods did not completely meet the needs of women and their families; nor would they alone have a sufficient demographic impact… Mifepristone (RU 38486)…”

Albrecht Durer - Draughtsman Drawing a Recumbent Woman. 1525. Woodcut.

Albrecht Durer - Draughtsman Drawing a Recumbent Woman. 1525. Woodcut.

Chemistry of Natural and Anthropogenic Endocrine-Active Compounds http://to.ly/5dkG . “…endocrine active compounds comprise both naturally occurring substances and man-made chemicals, and their chemical structures are surprisingly diverse… Phytoestrogens, Industrial Chemicals… The stilbene-type agents diethylstilbestrol (DES), E,E-dienestrol and meso-hexestrol were synthesized in the late 1930s and are among the first man-made estrogens used for human treatment… banned today…  The phenolic A ring of steroidal estrogens has long been considered a prerequisite for estrogenicity… also of paramount importance for the high estrogenic activity of DES and other stilbene-type compounds… it has been observed that numerous other phenols exhibit hormonal activity… potential endocrine disruptors, viz., alkylphenols and bisphenols… prototype of bisphenols is bisphenol A (BPA, Fig. 12), used in large amounts for the production of polycarbonate plastics and epoxy resins… Polychlorinated biphenyls (PCBs) are among the most persistent and ubiquitous environmental pollutants. Whereas the PCBs themselves have no or at best marginal estrogenicity, significant hormonal activity may be entailed to these molecules by hydroxylation [22].”

Albrecht Durer - The Martyrdom of the Ten Thousand. AD 1508

Albrecht Durer - The Martyrdom of the Ten Thousand. AD 1508

To help make some sense of the above, let the editor of Annals of Internal Medicine (http://to.ly/5dnr ) say this: “…in the field of synthetic substitutes for the female sex hormones, the essential point is the establishment of the fact that estrogenic activity is not exclusively a property of compounds structurally similar to the natural hormones [that is, possessing the phenanthrene nucleus]… a number of simpler substances having estrogenic properties…”

So, again, there is no “magic bullet”, there are inevitable side effects, associated with lack of specificity (the scientific term for “no magic bullet”).

Specific Clomid warnings are, for example, at emedzone site (.com/clomid-brand-tabs-aventis-pharma-p-149.html). To cite: The regimen in which Clomid should be used depends on the individual condition… and if HCG was used mid-cycle or not.

Albrecht Durer - The Dresden Altar. AD 1496

Albrecht Durer - The Dresden Altar. AD 1496

Clomid Warnings

Clomid can cause disturbed vision and blurred vision and therefore should be used with caution…

For those women who are planning to get pregnant, be warned that taking Clomid may result [in] multiple births and this may be harmful to the mother and to the fetus as well. (Note: Multiple births are also a very big problem for public health.)

Clomid may also be not advised for patients with the following medical conditions (note: these are conditions that may have caused the difficulty to conceive in the first place):

  • Endocrinal disorders
  • Thyroid problems
  • Live[r] diseases
  • Ovarian cysts and enlargement
  • Polycystic ovarian syndrome
  • Uterine fibroids
  • Any other chronic illnesses
  • Endometrial carcinoma
  • Vaginal bleeding

If you have any of the above-mentioned diseases, your doctor may advise you not to take Clomid or will significantly alter your dosage.

Clomid is also not advised for pregnant women as it is a drug in the pregnancy category X and may cause birth defects when taken by pregnant women.

Clomid is also not advisable for nursing mothers as it passes into the breast milk and may cause harm to the nursing infant. END QUOTE.

Albrecht Durer - Durer's Wife Agnes

Albrecht Durer - Durer's Wife Agnes

In addition, the use of fertility drugs may be associated with an increased chance of developing ovarian cancer, although there is an ongoing controversy over this: http://to.ly/5dmf , http://www.wordiq.com/definition/Ovarian_cancer .

Such are the reasons why popping pills is not the best. Not to attack big pharma, but all this chemicalization of life is a form of enslavement. More insidious than the slavery that was abolished centuries ago, more subtle. First, make them buy a drug that causes such and such side effects including the least spoken of, the premature aging of the cervix http://to.ly/5dMb ; the ensuing problems are then tackled with other drugs (like clomifene), and on and on it goes.

Let’s contemplate with Albrecht’s wife Agnes why it should be that too many pregnancies were the problem before chemical contraception, whereas today… Today, sub-fertility and infertility are on the up and up, while contraceptive failure statistics are in the picture, too, showing that about half of all pregnancies in the U.S. are unplanned, and that mature population of America uses surgical sterilization for birth control.

This is a man-made problem. See the next post about accelerated atrophy of vital cervical tissues (crypts) due to the man-made problem called the Pill (About atrophy, reproductive aging, and how it’s really not nice to fool Mother Nature – or with). And see the December 2011 post about Difficult to conceive – Google evidence that pregnancy complications and trying-to-conceive concerns shot up after the Pill launch in 1960s (this article reiterates and simplifies the take-home message put forward in the atrophy – aging – Mother Nature post; and two paintings of the Rape of Europa are showed there, too…).

Peri-vernal equinox tweets on #conceiving, #fertility status, achieving #pregnancy in the era of #infertility – “a modern epidemic”

March 20, 2010

NFP aficionados know that fertility awareness is for birth control, too

And language aficionados will know that the peri in the title does not refer to any “one of a large group of beautiful, fairylike beings of Persian mythology, represented as descended from fallen angels and excluded from paradise until their penance is accomplished.” Nor, for that matter, to “any lovely, graceful person.”

Peri or Paeri of Persian folklore and mythology

Peri or Paeri of Persian folklore and mythology

Peri is a prefix meaning “about” or “around” and “near”, appearing in loanwords from Greek [http://dictionary.reference.com/browse/peri]. Just like here, whereby we invoke the Spring Equinox – when the Sun rises exactly in the east, travels through the sky for exactly 12 hours and sets exactly in the west – this year on March 20. “And anyone standing on the equator at noon will not cast a shadow” [http://www.wilsonsalmanac.com/book/mar20.html]. Lovely!

So then, now for the tweets (a little edited, since here we do not have the 140 character limit, and – in the usual manner – with clickable links to further information, including the #hash tags).

1)         2009 sales of #fertility LH kits at $272M outpaced #pregnancy tests http://to.ly/1p8Q Not exactly surprising since ~30% of US women do not get #pregnant in 6 or 12 months 12:04 PM Mar 16th

2)         #Infertility is “a modern epidemic”. In 17 studies, 56% of the relevant sub-population (range 42–76%) in developed countries sought medical help http://to.ly/1pdo but less than 1/2 of them received care 2:30 PM Mar 16th

3)         Unintended pregnancies = “global epidemic”. US family planning is “uniquely deficient” (50%) http://to.ly/1pcB Cause: high contraceptive failure rates 2:34 PM Mar 16th

4)         Leading causes of unintended pregnancy are closely related to #contraceptive failure. Failure rates: 31% the Pill, 18% condoms, 5% 3-month injectable #birth control 2:43 PM Mar 16th

5)      Medscape OBGYN: #fertility awareness can be highly satisfactory #birth control & #family planning method http://to.ly/1peK http://to.ly/1peM 3:14 PM Mar 16th

6)      RT @bioZhena #fertility awareness [FA] is a great #birth control & #family planning method especially for women 30+ years of age, and those who are able to practice FA without a teacher 3:23 PM Mar 16th

7)      Statisticians: Best frequency of sex for unfocused conception attempts is every 2 or 3 days http://bit.ly/d9tCfm to avoid exhaustion. Else, everyday 5:32 PM Mar 16th

8)      RT@bioZhena But even sex every day for 20 days from day 6 to day 25 only computes as 69% probability of conception. So what else is new in the world of sub- #fertility, wanting #pregnancy but being put into the sub- #fertile category 5:34 PM Mar 16th

9)      Trying to get #pregnant without knowing when-to frequently does not work for a long time. Yet, often all that’s needed is knowing your actual fertile window in the present cycle http://to.ly/VCF 7:18 PM Mar 16th

10)  For #fertilityawareness, NFP for #pregnancy and/or #birthcontrol, we have the tool for you http://to.ly/VCF — or, rather, will have, once funded. Comments? 7:19 PM Mar 16th

What Women Know, And What They Want To Know About Their Fertility Status

October 10, 2009

There: What Women Know

There is no device in the marketplace today that would tell you, in plain English, “today is your fertile day 1” – meaning that sex today is likely to lead to pregnancy. And from our clinical trial results you will know that the pregnancy conceived on this first of the fertile days is likely to be a male fetus, a boy.

There is no such device on the market that would subsequently confirm the pregnancy within days – when, after ovulation on fertile day 3, you – or, rather, your Ovulona device for you – will no longer register the usual follicular waves. Your Ovulona device will interpret that as pregnancy detected, because that is how the biology works.

There is no device out there that would identify the only 3 days in each menstrual cycle during which – and only during which – pregnancy can result from insemination, whether natural or artificial. The commercially available fertility monitors cannot detect either delayed ovulation (which happens due to stress) or when ovulation does not occur at all. In fact, they do not detect ovulation, they just guess at it.

Because the currently marketed fertility monitors (ovulation predictors) cannot detect ovulation, they merely assume its occurrence due to the particular hormonal marker-predictor of their choice (usually LH, in some cases estrogen, in one case both). But no single hormone, even if it were detected with the accuracy of laboratory methods, determines the fertile window. It’s much more involved than that.

Here: What Women Want To Know

Only scarcity of funds keeps us from marketing a device doing all those things not available today.

Our personal self-diagnostic device, the Ovulona™, will tell the woman user in plain English (or any other language) whether today is one of the three days when she can become pregnant.

https://biozhena.files.wordpress.com/2009/10/fertile-window1.jpg?w=600

Fertile window

How? We’ll have the woman monitor at home the process that causes menstrual cycles and is fundamental to women’s health. The use of the Ovulona device is very simple, just like a tampon, except that it is inserted for only a few seconds (about 20) to obtain the result, with an instant display of the result.

Primary use is for reproductive management – that is aiding the achievement of pregnancy, and also aiding fertility-awareness based non-invasive birth control. But there is much more, including an automatic screening for cervical cancer, management of PMS/PMDD and management of hormone therapy, to name just a few useful applications that will come with the core technology.

We show the working of the prototyped product using the graphs of the measurement results plotted against the days of the menstrual cycle. The graphs produce cyclic profiles descriptive of the nuances of the monitored menstrual cycles. None of the old techniques can do that.

These cyclic profiles have important characteristics:

1. The cyclic profile has numerous repeatable features.

2. The range of readings is the same in different cycles and, importantly, also in different women.

3. The profile features are interpretable, and are due to the biological process that causes the menstrual phenomena (folliculogenesis).

The significance of these profiles goes beyond reproductive management.

To wit: Ours is a unique and disruptive technology.

https://biozhena.files.wordpress.com/2009/10/fertile-window-for-birth-control.jpg?w=600

Fertile window for birth control

For a better insight, visit the other posts on this blog [ https://biozhena.wordpress.com/ ], and check out http://www.linkedin.com/in/vaclavkirsner.

Before you go, see this, to get a sense of what is going on here:

https://biozhena.files.wordpress.com/2009/10/baseline-cycles-interpreted.jpg?w=600

Baseline cycles interpreted

Not included in this illustration is the use of the follicular waves for early pregnancy detection (the waves disappear; the right term for this is “instant pregnancy detection”), and monitoring for early pregnancy loss (in that unfortunate eventuality, the waves come back; it is advisable – by certain recent findings – that the couple should not delay trying to conceive again). Refer to the following for more about said recent findings: original medical publication in BMJ http://to.ly/9WtG; BMJ editorial comment http://to.ly/9WtI; CNN.com article “Miscarriage? Try again ASAP, study suggests” http://ht.ly/2mlwb; bioZhena’s post http://to.ly/802p “Instant detection of pregnancy and of Early Pregnancy Loss, EPL – the adversary of Trying To Conceive, TTC – especially after age 25”.

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Parties with an interest relevant to bioZhena Corporation will be provided with more confidential information upon request (email: vaclav@biozhena.com). Visit the company at http://www.biozhena.com/ .


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