BIOZHENA’S MISSION: A HEALTH TOOL FOR EVERY WOMAN

Our mission is to commercialize a product that practically every woman will want to use. Because most every woman wants to know her fertile status, her menstrual cycle, her cervical health. And will want to have her menstrual cycle  and cervical health data available for her physician when needed.

>>> We provide for that. By tracking the menstrual cycle via the uterine cervix (outer cervix wall), thus recording the diagnostically useful cyclic profile that anticipates and then detects ovulation.

The importance of detecting ovulation in addition to anticipating it quantitatively cannot be over-emphasized (because synchronization of brain and ovarian pacemakers is a prerequisite of ovulation and the process must be monitored since the prerequisite synchronization often complicates things). That is why the technique detects effects of stress on women’s fertility and provides for management of those effects (see below). 

RIGHT UPFRONT, NOTE WELL:

THIS IS NOT ANOTHER OVULATION TEST KIT!

What is folli+HPG w. innerv AND Wealth of info+Correl w. symptometry vertical - ee

Click the image to enlarge it.

Folliculogenesis is the mechanism of the menstrual cycle, which is monitored by the cervix. And we monitor the cervix.

Our “elevator pitch” must therefore highlight that the bioZhena’s technology platform is bound to revolutionize women’s healthcare with diagnostic tools for women and for their doctors & payers (insurers).

Sixty years after the introduction of oral contraception many women have grown unhappy with the side effects. Many are turning to fertility awareness, for which there is a large and growing market among the population suffering with sub-fertility, the difficulty to get pregnant.

We aim to empower every woman with a self-care monitoring tool that provides a clear-cut daily indication of whether she can get pregnant today or not, and we empower doctors with the menstrual cyclic profile signatures thereby recorded by the women at home.

The Menstrual Cycle is a Vital Sign® An Indicator of Overall Health.

Significant benefits to women’s healthcare ensue from the introduction of the vital-sign recording Folliculogenesis-In-VivoTM medtech platform, which has a broad applicability because much in women’s life revolves around the menstrual cycle.

Physicians need the means with which to assess the menstrual cycle and its variability, both normal and the many abnormal, which our technology provides.

Everybody benefits from the innocuous screening of cervical health that will take place concurrently with the fertility monitoring – convenient, hassle-free and pain-free, and eminently affordable. Much better as a screen than the Pap smear test.

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While we’ll obviously launch first the FDA-cleared conception-aiding application, many women have told us that they would switch from their current contraception method when our monitor becomes available.

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Ovulona - single slide 3-day fertile window

Click on the image (or here) to view the slide showing how the menstrual cyclic profile defines the daily fertility status, and how it relates to the basal body temperature (BBT), with which you are probably familiar.

The 3-day fertile window is clearly detected by the monthly signature profile generated by the Ovulona™ and translated electronically into indications FERTILE DAY 1, FERTILE DAY 2, FERTILE DAY 3 = OVULATION.

And yes, it is those 3 days – click here for why.

That is, those 3 days unless the menstrual cyclic profile recorded by the Ovulona detects a delay of ovulation with respect to the hormones anticipating ovulation (estrogen and LH) as seen in https://biozhena.files.wordpress.com/2019/01/single-slide-ovulona-detects-delayed-ovulation-w.-links.pdf .

You can also read the blog page at   https://biozhena.wordpress.com/stress-and-fertility-fertile-window-ovulation/  and see that the data was generated in two pilot studies by independent investigators testing the Ovulona prototypes.

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>>> Significantly, as hinted above in the “elevator pitch” block-quote, there is much more to this cervix-monitoring technology:

 

Not just for achieving pregnancy and not just for avoiding pregnancy. Our core product, the Ovulona™ monitor, is the core of a new women’s healthcare diagnostic technology platform.

bioZhena’s technology is bound to revolutionize women’s healthcare with diagnostic tools for women and for their doctors & payers (insurers).

The woman of the 21st century is envisaged to become accustomed to using her quick and easy daily fertility (menstrual cycle) self-check about as routinely as she is using her toothbrush. Because most women’s cycles vary from one cycle to the next and so does also the ovulation day.

Too many menstrual cycles are irregular due to a mismatch between the brain and the ovarian pacemakers, and it’s also a fact that many “clinically normal cycles” are in fact anovulatory (without ovulation, hence unable to conceive). See below how this technology helps healthcare providers to better manage women’s menstrual cycle issues.

 

Friendly Technology - Data from home to the Ovulograph

Click the image for better legibility and animation

(Slide takes a few moments to open.)

>>> And the physicians’ benefit?

 

Menstrual cycle profile records (Folliculogenesis-In-Vivo records) for better diagnosis – much like the EKGs for heart doctors – but not as “granular”. 

Essential for correct timing of procedures and tests.

The menstrual cyclic profiles are periodically recurring signatures of the 5th vital sign of female patients – diagnostically meaningful and useful especially when correlated with symptometric data (such as charted quantified symptoms enabling differential diagnosis). 

The ovulographic in-vivo monitoring of folliculogenesis is believed to capture the fine-tuning effects on folliculogenesis of the direct neural control via ovarian and uterine innervation and the acute effects of local (autocrine and paracrine) modulatory actions.

You can see here again the example of detecting  the delay of ovulation which causes the delay of the whole 3-day fertile window. Take this as a hint at the diagnostic possibilities to detect and better manage the many occurrences of ovulatory dysfunction in normal healthy women. Check it out.

 

Hypothalamus-P-G Feedback and innervation panorama with text (stress)

 

Those effects cannot be detected by monitoring the systemic peripheral variables such as the BBT (Basal Body Temperature) or the urine levels of hormones monitored by the commercially available home-use technologies.

In contrast to the old methods, see  https://biozhena.files.wordpress.com/2019/01/Single-slide-How-the-Ovulona-will-help-physicians.pdf  for how our technology will help physicians to better help their female patients.

See how the Ovulona anticipates failure to ovulate in a healthy woman, and how the Ovulona detects delayed ovulations in asynchronous cycles that happen to many healthy women. These occurrences are where the neurological effects are believed to play a role.

Our technology should bring personalized evidence insight into the management of women’s health ailments such as PCOS, the Polycystic Ovary Syndrome, to improve on current practice of testing different treatments by “comparison made on the average group effects”.

Similar reasoning (the need for personalized diagnostic evidence) applies to the management of autoimmune disease. That’s because sex hormones regulate the development and function of the immune response (the link is to the last tweet of a thread of three tweets discussing Sex Hormones in Acquired Immunity and Autoimmune Disease).

Read more About bioZhena’s Vision to enable actionable decisions that will contribute to the trend toward Value-Based Women’s Healthcare.

Nota Bene, Note This Well:

The important advantage is that the cyclic profile records – plus the cervical health testing – will be done in the comfort of the home and at a very affordable cost.

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Provided that you are a well-matched investor or a prospective bioZhena Corporation management team candidate, please visit   https://biozhena.wordpress.com/and-for-investors-ppm/.

Make sure that you have not skipped the overview of the bioZhena project at https://biozhena.wordpress.com/the-biozhena-project/ .

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