About bioZhena – tech pitch

Women’s reproductive health in vivo diagnostics

How we’ll befriend one half (the better half :-)) of humankind… We’ve solved the problem of detecting your daily fertility status – can you get pregnant today or not – by monitoring folliculogenesis in vivo. In so doing, we have a handle on numerous aspects of women’s health. Read on to appreciate this.

The screenshot of the slide on the left below indicates that the user of the Ovulona device will receive interpreted diagnostic results in simple language (either FERTILE [with fertile-day number] or – mostly – NOT FERTILE) — without the need for any charting, the data evaluation being done electronically, right away. And the display will also indicate, when appropriate, PREGNANCY DETECTED, or SEE DOCTOR (this upon detecting cervical tissue aberration during several consecutive menstrual cycles, reproducing the condition before raising the concern).

That we can give the user interpreted diagnostic results in plain language is thanks to the rich information content of the monitored menstrual cyclic profile, which is the result of our method of measurement. “Rich information content” refers to the numerous peaks and nadirs in the profile – the features associated with the individual stages of folliculogenesis.

In the screenshot of the slide on the right is an example of the menstrual cyclic profiles (aka folliculogenesis profiles) generated with our personal home-use monitor by a subject of a small clinical study. The lower curve is the morning data while the profile with the higher signal amplitudes is the evening data. At the bottom is the BBT data for comparison.

ovulona-illustrated-in-two-slides1Click on the image for an animation of the 3-day fertile window

The picture on the right shows that during the days of the fertile window (the 3 days marked with the green on the time axis), the AM-PM difference is practically indistinguishable, whereas outside of the fertile period of 3 days the signal grows between the morning and evening hours – as the folliculogenesis process progresses with time.

The BBT or Basal Body Temperature profile, seen in the lower part on the right of the image, was measured by the same woman in the usual manner. The BBT is NOT a part of our monitoring process; it’s shown here merely as a convenient reference that quite a few people are familiar with.

The various features of our menstrual cyclic profile correspond to the various stages of the folliculogenesis process. This includes the dominant follicle maturation in the early pre-ovulation phase of the cycle, and the follicular waves in the post-ovulation, pre-menstrual, phase of the cycle.

In the post script below, you can see the slide enlarged and animated. The fetal gender pre-selection pointers are based on studies discussed elsewhere in bioZhena’s Weblog. (Should your physician raise a doubt about the indicated fetal gender pre-selection principle, then chances are that he or she is not familiar with the studies referenced therein. They should not ignore the fundamentals.)

The bioZhena project involves an electronic device technology developed to make it possible that every pregnancy is deliberate, and to impact on women’s healthcare and public health in other ways, too. The latter because much in women’s health revolves around the menstrual cycle.

In 2015 (some years after this tech pitch was first published), I share this diagram, and I emphasize that the market of ovulation predicting and estimating products offers anything else but what is actually needed, namely monitoring of the brain-ovary feedback loop (F) indicated in the diagram, i.e. the Hypothalamus-Pituitary-Gonad Feedback Loop.

Hypothalamus-Pituitary-Gonad Feedback Loop

That is what our tissue biosensor does by interfacing with the cervix uteri, the natural monitor of the interactions between the brain and the ovaries. Those are the interactions that result in the phenomena of menstrual cycle. Like blood pressure and heart rate, a woman’s menstrual cycle is a vital sign of her overall health. bioZhena’s cervical sensor provides the menstrual cycle signature and is the core of a new technology platform.

The Menstrual Cycle is a Vital Sign® and our technology captures the vital-sign signatures for long-term monitoring by physicians who can receive the data from the patients’ devices. A set of 5 slides tells more (animated slides, progressing automatically but you can pause and navigate back and forth).

Our ovulographic™ technology is the definitive answer to the basic need of women everywhere – natural and affordable reproductive management. You can actually know your menstrual cycle progress every day.

Reiterating: The personal self-diagnostic device, the Ovulona™, will tell the woman in plain English (or Spanish, German, Chinese, Arabic, etc.) whether today is one of the three days that she can become pregnant. A three day fertile window, unless stress causes delayed ovulation or suppresses ovulation completely, either of which is then detected, too.

Prospectively, this will be accompanied by cervical health screening automatically going on in the background. And then there will be additional uses of the measurement data, such as: Early pregnancy detection (I should say, instant pregnancy detection built-in); data-based forecast of the EDD, Estimated Date of Delivery; management of PMS/PMDD; management of hormone therapy, to mention a few… and not to mention fetal sex pre-selection. Or pregnancy monitoring for better management of birthing.

With the exception of the pregnancy monitoring topic, the other issues and applications are discussed in the various posts of this bioZhena’s Weblog. You can refer to the Table of Contents = links to bioZhena posts (recommended – if only because Reproductive Health IQ Does Matter).

The longitudinal folliculogenesis data – acquired over many menstrual cycles and stored in the Ovulona device – can be optionally provided to the woman’s physician(s) and the healthcare system. This represents a novel way of patient profiling. And a telemedicine tool.

The Ovulona is clearly not another ovulation kit only for those who find it difficult to become pregnant.

We position the Ovulona to be a product that practically every woman will want to use . The woman of the 21st Century is envisaged to become accustomed to using her daily Ovulona self-check about as routinely as she is using her toothbrush.

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So, now, right after this pictorial intermezzo with Picasso, Kirchner and Picasso…

70% of women - cropped

         … go to check out the animated pictorial  Tweetroducing bioZhena in 8 slides

In the third slide you’ll see the above images in their full glory!

In the seventh slide, cervical health testing costs might intrigue you? See the estimates at Costs of the Pap smear test vs. the cost of the Ovulona

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bioZhena Corporation seeks financing with which to manufacture the first batch of our first marketable product within a few months, the first milestone towards market dominance in Scientific Family Planning™. The first Ovulona application for use as a conceptive aid for women and their physicians (to help achieve pregnancy, as opposed to the birth control use and the cervical health screen) has already been FDA-certified. Profits from the sales of the first application will fund the testing and launch of the next next applications of the Ovulona™ – and of the healthcare providers’ Ovulograph™.

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Post Script

More about the folliculogenesis (menstrual cycling) profile as generated by the Ovulona device

The purpose of this post script is to give the interested reader a chance to see better the data shown and discussed in the introduction above. The slides appear in the PPS mode, which you can navigate by means of the buttons that appear in left bottom corner of the PPS screen upon moving the cursor over the screen.

biozhena-corp-single-slide-3-day-window

If interested further, then you should see the aberrant cyclic profile and its interpretation – for the implication therein of the diagnostic possibilities of this simple-to-use diagnostic tool made to be used by women at home and optionally providing essential data to their physicians when medical help is sought.

Fertile window and LPD and text, 3 slides

Should you be really curious about how it can be that the Ovulona works the way it does (that it tracks folliculogenesis and thus can do what the commercially available ovulation predicting products and methods cannot do), let me offer you a readable hint.

You can read in http://science.howstuffworks.com/life/inside-the-mind/human-brain/brain-during-orgasm.htm how “all of the genitalia contain a huge number of nerve endings”. And, “they perform many other functions in the body in addition to providing the nerve supply, and therefore feedback to the brain, during sexual stimulation.”

Of course, said article is not about the Ovulona, but you’ll read that the cervix is serviced by at least three nerves named in the article (hypogastric, pelvic, and vagus). “Excessive activation of the vagal nerve during emotional stress, which is a parasympathetic overcompensation of a strong sympathetic nervous system response associated with stress… affects young children and women more than other groups.”

What is the significance of this? Folliculogenesis is not merely a process involving hormonal signals – it’s a process of integration of all neuroendocrinological inputs, which the cervix monitors. And the Ovulona monitors the cervix.

Last but not least, don’t overlook this implication: Once we get many women to use the Ovulona as a reproductive management tool, with the cervical health screen going on innocuously in the background (without causing any discomfort or anxiety), we will have put into effect a very important cervical health screening tool that will significantly impact public health and lives of women everywhere.

Contact me if interested – for a good professional reason – via email: vaclav@biozhena.com . Read my LinkedIn profile first. Business particulars are not for public disclosure – will be shared as and if appropriate.

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3 Responses to “About bioZhena – tech pitch”

  1. Laverne Crickmore Says:

    thanx for excellent content

  2. The Alphabet of bioZhena — Abeceda bioŽeny « bioZhena's Weblog Says:

    […] of the two About pages – one about the blogger and the issues covered here , and the other About bioZhena – tech pitch . See if both these pages include the link to a quick pictorial summary of the bioZhena project, […]

  3. The Ovulona™ | bioZhena's Weblog Says:

    […] See also bioZhena Tech Pitch at https://biozhena.wordpress.com/about/about-biozhena-tech-pitch/ […]

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